有机化学 ›› 2022, Vol. 42 ›› Issue (12): 4202-4219.DOI: 10.6023/cjoc202204037 上一篇    下一篇

所属专题: 自由基化学专辑

综述与进展

硫/硒代磺酸酯作为自由基试剂的应用研究

于婷婷, 宋冬雪, 许颖, 刘冰, 陈宁, 刘颖杰*()   

  1. 哈尔滨商业大学药学院 哈尔滨 150076
  • 收稿日期:2022-04-14 修回日期:2022-07-07 发布日期:2022-09-01
  • 通讯作者: 刘颖杰
  • 基金资助:
    黑龙江省自然科学基金优秀青年(YQ2019B004)

Study on the Application of Thios/Selenium Sulfonates as Radical Reagent

Tingting Yu, Dongxue Song, Ying Xu, Bing Liu, Ning Chen, Yingjie Liu()   

  1. School of Pharmacy, Harbin University of Commerce, Harbin 150076
  • Received:2022-04-14 Revised:2022-07-07 Published:2022-09-01
  • Contact: Yingjie Liu
  • Supported by:
    Outstanding Youth Project of Natural Science Foundation of Heilongjiang Province(YQ2019B004)

硫/硒代磺酸酯是天然产物、合成的生物活性分子和上市药物中的关键结构骨架, 同时也是有机合成中重要的构建原料, 被广泛应用于药物分子和材料科学. 随着过渡金属催化、光催化以及电催化自由基反应的迅速发展, 自由基化学在合成领域取得了突破性进展, 硫/硒代磺酸酯作为自由基试剂的应用也受到了广泛的关注. 分别阐述了近年来快速发展的金属催化、可见光催化、金属和光协同催化以及其它类型催化中硫/硒代磺酸酯作为自由基试剂的应用研究, 并对部分反应的机理进行了详细论述.

关键词: 硫/硒代磺酸酯, 自由基, 催化

Thios/selenium sulfonates are key structural skeletons in natural products, synthetic bioactive molecules and marketed therapeutic drugs, as well as important building material in organic synthesis, and are widely used in drug molecules and materials science. With the rapid development of transition metal-catalyzed, photocatalytic and electrocatalytic radical reactions, breakthroughs in radical chemistry have been achieved in the field of synthesis. Therefore, the applications of thios/selenium sulfonates as radical reagent have attracted extensive attention. The applications of thios/selenium sulfonates as radical reagent in metal catalysis, visible light catalysis, metal-light synergistic catalysis and other types of catalysis, which have been developed rapidly in recent years, are reviewed, and the mechanisms of some reactions are discussed in detail.

Key words: thios/selenium sulfonate, radical, catalysis