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有机化学
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有机化学 ›› 2010, Vol. 30 ›› Issue (01): 23-37. 上一篇    下一篇

综述与进展

同位素标记及未标记的1-脱氧-D-木酮糖-5-磷酸和2-甲基-D-赤藓糖醇-4-磷酸的合成方法

高文运   

  1. (西北大学生命科学学院 国家微检测系统工程技术研究中心 西安 710069)
  • 收稿日期:2009-02-20 修回日期:2009-05-08 发布日期:2010-01-20
  • 通讯作者: 高文运 E-mail:gaowenyun@nwu.edu.cn
  • 基金资助:

    国家级.国家自然科学基金

Preparation of Isotope Labeled/Unlabeled 1-Deoxy-D-xylulose 5-Phosphate and 2-Methyl-D-erythreitol 4-Phosphate

Gao，Wenyun   

  1. (National Engineering Research Center for Miniaturized Detection Systems，College of Life Sciences， Northwest University，Xi'an 710069)
  • Received:2009-02-20 Revised:2009-05-08 Published:2010-01-20

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3362

被引次数

22

萜类化合物构成了最大的一个天然产物家族，结构复杂多变，且有许多重要的生理活性。2-甲基-D-赤藓糖醇4-磷酸(MEP)途径是近年来发现并建立的一条萜类化合物的生物合成途径，其中所涉及到的酶均可作为靶标来进行新抗菌素的筛选。综述了以化学合成及酶催化合成方法制备MEP途径中关键中间体1-脱氧-D-木酮糖5-磷酸和2-甲基-D-赤藓糖醇4-磷酸的进展，并着重介绍了同位素标记的这两个化合物的制备方法.

关键词: 萜类化合物, 生物合成, MEP途径, 中间体, 同位素标记

Naturally occurring terpenes constitute the largest group of natural products with complicated and variable structures and a great number of important biological activities。2-Methyl-D-erythreitol 4-phosphate (MEP) pathway is a newly found and established biosynthetic route for terpenoids and all the enzymes involved in this pathway can be used as targets for the screening of new antibiotics。Progress in chemical and enzymatic preparation of the key intermediates in MEP pathway，namely 1-deoxy-D-xylulose 5-phosphate and 2-methyl-D-erythreitol 4-phosphate is reviewed with the emphasis on the synthesis of these two compounds with isotope labels.

Key words: terpenoid, biosynthesis, MEP pathway, intermediate, isotope label