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有机化学
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有机化学 ›› 2003, Vol. 23 ›› Issue (11): 1264-1266. 上一篇    下一篇

研究论文

镍络合物催化条件下2,2'-联吡啶的偶联合成

钱延龙;王晨;陶晓春;黄吉玲   

  1. 华东理工大学金属有机化学研究室
  • 发布日期:2003-11-25

Synthesis of 2,2'-Bipyridine through Catalitic Coupling Reaction of α-Brompyridine Using Nickel Complex

Qian Yanlong;Wang Chen;Tao Xiaochun;Huang Jiling   

  1. Laboratory of Orgonometallic Chemistry, East China University of Science and Technology
  • Published:2003-11-25

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1404

被引次数

42

在制备联吡啶的偶联反应中，镍化合物和三苯基膦通常是以化学计量参与反应 。我们在对Tiecco报道的偶联反应进行研究的过程中发现，这一反应可以在催化条 件下进行。这一改进订基于投料顺序的改变，充分利用零价镍当场（in situ）生 成时的高活性。将氯化镍、三苯基膦、2-溴吡啶先溶于DMF中，然后在50 ℃时加入 锌粉，催化偶联生成联吡啶，可以获得满意的收率。同时对三种镍化合物的反应活 性作了比较，以NiCl_2·6H_2O活性最高。

关键词: 吡啶 P, 联吡啶, 偶联, 催化反应, 镍化合物, 催化活性

Ni compounds and PPh3 were usually used in stoichiometric amounts for the synthesis of bipyridine via coupling reaction. This reaction procedure was improved by using only catalytical amounts of nickel and PPh3 in the presence of zinc. This modification was mainly based on the changes of reaction addition order which could sufficiently utilize the Ni(0) generated in situ. Bipyridine can be synthesized by this catalytical procedure with satisfactory yield. The activity of three kinds of Ni complexes was compared in the reaction, and NiCl_2· 6H_2O represented the highest activity.

Key words: PYRIDINE P;BIPYRIDINE;COUPLED;CATALYTIC REACTION;NICKEL COMPOUNDS, CATALYTIC ACTIVITY

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