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有机化学
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有机化学 ›› 2011, Vol. 31 ›› Issue (04): 443-452. 上一篇    下一篇

综述与进展

铜-手性氮杂环卡宾化合物催化的不对称1,4-共轭加成反应

于艳飞1，单凤军1，李争宁*,1,2，姜岚1   

  1. (1大连大学环境与化学工程学院 大连 116622)
    (2辽宁省生物有机化学重点实验室 大连 116622)
  • 收稿日期:2010-02-24 修回日期:2010-07-20 发布日期:2010-10-10
  • 通讯作者: 李争宁 E-mail:znli@dl.cn;znli2002@hotmail.com
  • 基金资助:

    新型金属-手性NHC 化合物的合成和不对称催化性能研究

Asymmetric 1,4-Conjugate Addition Reactions Catalyzed by Cu-Chiral N-Heterocyclic Carbene Complexes

Yu Yanfei1 Shan Fengjun1 Li Zhengning*,1,2 Jiang Lan1   

  1. (1 College of Environmental and Chemical Engineering, Dalian University, Dalian 116622)
    (2 Liaoning Key Laboratory of Bioorganic Chemistry, Dalian 116622)
  • Received:2010-02-24 Revised:2010-07-20 Published:2010-10-10
  • Contact: LI Zheng-Ning E-mail:znli@dl.cn;znli2002@hotmail.com

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被引次数

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近年来, 利用金属-手性氮杂环卡宾(NHC)化合物进行不对称催化反应已取得了快速发展. 相关报道越来越多, 一些反应已获得良好的对映异构体选择性, 这显示出金属-NHC化合物在催化合成手性化合物中的潜在用途. 按NHC为单齿、双齿配体总结了金属-手性NHC化合物对α,β-不饱和酮的共轭加成反应的不对称催化, 以期对发现高立体选择性金属-NHC催化剂提供一些启发.

关键词: 金属-NHC化合物, 铜, 不对称催化, 共轭加成

Rapid advance has been achieved in the asymmetric catalysis using metal-chiral N-heterocyclic carbene (NHC) complexes as the catalysts in recent years. Increasing number of reports in this field and high enantioselectivities obtained under the catalysis of metal-NHC complexes have demonstrated the potential importance of metal-chiral NHC complexes in the catalytic, asymmetric synthesis of chiral compounds. Metal-chiral NHC complexes-catalyzed conjugate addition of α,β-unsaturated carbonyl compounds is reviewed. The results are summarized according to the ligated mode of NHC, from mono dentate to bidentate, with an intention to promote the design and discovery of high stereoselective catalysts with NHC ligands.

Key words: metal-NHC complex, copper, asymmetric catalysis, conjugate addition