有机化学 ›› 2021, Vol. 41 ›› Issue (9): 3459-3481.DOI: 10.6023/cjoc202103032 上一篇    下一篇

所属专题: 有机电合成虚拟专辑 有机光催化虚拟合辑

综述与进展

光/电化学合成在喹喔啉-2(1H)-酮C—H键官能化中的应用

刘想*(), 李文, 庄灿展, 曹华   

  1. 广东药科大学医药化工学院 广东省化妆品工程技术研究中心 广东中山 528458
  • 收稿日期:2021-03-19 修回日期:2021-04-04 发布日期:2021-06-07
  • 通讯作者: 刘想
  • 基金资助:
    国家自然科学基金(22001045); 广东省创新强校项目(2019KQNCX061); 省市共建重点学科建设专项资助项目.

Application of Photochemical/Electrochemical Synthesis in C—H Functionalization of Quinoxalin-2(1H)-one

Xiang Liu(), Wen Li, Canzhan Zhuang, Hua Cao   

  1. Guangdong Cosmetics Engineering & Technology Research Center, School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Zhongshan, Guangdong 528458
  • Received:2021-03-19 Revised:2021-04-04 Published:2021-06-07
  • Contact: Xiang Liu
  • Supported by:
    National Natural Science Foundation of China(22001045); Innovation and Strong School Project of Guangdong Pharmaceutcal University(2019KQNCX061); Special Funds of Key Disciplines Construction from Guangdong and Zhongshan Cooperating.

喹喔啉-2(1H)-酮是一类重要的含氮杂环化合物, 具有很强的生物活性与化学特性, 在合成化学、功能材料及药物工业等方面具有重要应用. 近年来, 通过C—H官能化构建3-官能化的喹喔啉-2(1H)-酮引起了很多学者的关注, 并取得了重要进展. 其中, 基于绿色化学导向的光催化及电化学合成正成为喹喔啉-2(1H)-酮的C—H官能化的强有力工具. 鉴于光电化学在合成化学中的巨大影响, 总结了可见光催化与电化学合成实现喹喔啉-2(1H)-酮3位C—H官能化的研究现状, 希望能促进绿色合成策略在含氮杂环官能化中的进一步发展.

关键词: 喹喔啉-2(1H)-酮, 可见光, 电化学, C—H官能化

Quinoxalin-2(1H)-ones are a kind of important nitrogen-containing heterocyclic compounds, which have strong biological activity and chemical properties, and play an important role in synthesis chemistry, functional materials, drugs and so on. In recent years, the construction of 3-functionalized quinoxalin-2(1H)-one by C—H functionalization has attracted the attention of many scholars and made important progress. Among them, green chemistry oriented photocatalysis and electrochemical synthesis are becoming powerful tools for C—H functionalization of quinoxaline-2(1H)-one. In view of the great influence of photochemistry in synthetic chemistry, the research status of C—H functionalization of quinoxaline- 2(1H)-one in visible light catalysis and electrochemical synthesis is summarized, hoping to promote the further development of green synthesis strategy in the functionalization of nitrogen-containing heterocycles.

Key words: quinoxalin-2(1H)-one, visible-light, electrochemistry, C—H functionalization