有机化学 ›› 2022, Vol. 42 ›› Issue (10): 3152-3166.DOI: 10.6023/cjoc202207036 上一篇    下一篇

所属专题: 不对称催化专辑

综述与进展

过渡金属催化的不对称氢酰化反应研究进展

王豪锐, 叶萌春*()   

  1. 南开大学化学学院 元素有机化学国家重点实验室 天津 300071
  • 收稿日期:2022-07-26 修回日期:2022-10-05 发布日期:2022-11-02
  • 通讯作者: 叶萌春
  • 基金资助:
    国家自然科学基金(21871145); 国家自然科学基金(22188101); 可持续化学转化海河实验室和南开大学新物质科学中心(63181206)

Research Advance on Enantioselective Transition Metal-Catalyzed Hydroacylation Reactions

Haorui Wang, Mengchun Ye()   

  1. State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071
  • Received:2022-07-26 Revised:2022-10-05 Published:2022-11-02
  • Contact: Mengchun Ye
  • Supported by:
    National Natural Science Foundation of China(21871145); National Natural Science Foundation of China(22188101); Haihe Laboratory of Sustainable Chemical Transformations and the “Frontiers Science Center for New Organic Matter”, Nankai University(63181206)

过渡金属催化醛和π-不饱和键的氢酰化反应具有原料来源广泛、价廉易得的优点, 且具有高的原子和步骤经济性, 为C—C键的构筑提供了一条经济而高效的途径. 因此, 近几十年来, 该反应受到了持续而广泛的关注. 此篇综述将对过渡金属催化的不对称氢酰化反应的研究进展进行总结, 详细阐述反应类型、不对称控制方法和反应机理等.

关键词: 过渡金属催化, 氢酰化反应, 不对称催化, 醛, 烯烃

Transition metal-catalyzed hydroacylation reaction of aldehydes with π-unsaturated compounds provides an economical and efficient method for the construction of C—C bonds, not only allowing readily available starting materials to be used as substrates, but also featuring high atom and step economy. Therefore, the reaction has received continuous and extensive attention during the past several decades. The advances on enantioselective transition metal-catalyzed hydroacylation reactions are summarized, focusing on reaction types, asymmetric strategies and reaction mechanisms.

Key words: transition metal catalysis, hydroacylation, asymmetric catalysis, aldehydes, alkenes