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综述与进展

金鸡纳生物碱及其衍生物在不对称催化中的研究进展

许双花, 陈俊, 陈加荣, 肖文精   

  1. 华中师范大学化学学院 武汉 430079
  • 收稿日期:2020-07-01 修回日期:2020-08-01 出版日期:2030-01-01 发布日期:2020-08-11
  • 通讯作者: 陈加荣, 肖文精 E-mail:chenjiarong@mail.ccnu.edu.cn;wxiao@mail.ccnu.edu.cn
  • 基金资助:
    国家自然科学基金(No.21820102003,91956201)资助项目.

Recent Progress in Applications of Cinchona Alkaloids and their Derivatives in Asymmetric Catalysis

Xu Shuang-Hua, Chen Jun, Chen Jia-Rong, Xiao Wen-Jing   

  1. College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, China
  • Received:2020-07-01 Revised:2020-08-01 Online:2030-01-01 Published:2020-08-11
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 21820102003, 91956201).

金鸡纳生物碱广泛存在于自然界中,具有很好的生物活性和药用价值,且具有优势的手性骨架,易于修饰,引起了人们广泛的研究兴趣。随着不对称合成化学的发展,化学家们将金鸡纳生物碱及其衍生物作为优势手性催化剂或配体应用于许多不对称催化反应中。尤其是近年来,有机化学家们利用金鸡纳生物碱衍生的手性配体发展了一系列金属催化不对称反应。本综述较为详细地概述了近年来金鸡纳生物碱及其衍生物作为催化剂或配体参与的不对称催化反应,探讨了相关反应机理,并对该研究领域未来发展前景进行了展望。

关键词: 金鸡纳碱, 有机催化剂, 手性配体, 不对称合成, 不对称催化

Cinchona alkaloids widely exist in nature, which have attracted extensive interest of researchers because of their readily availability, biological activity, unique structural properties, and easy modification. With the development of asymmetric synthetic chemistry, cinchona alkaloids and their derivatives have been used as a privileged class of chiral catalysts or ligands in many catalytic asymmetric reactions. In particular, a variety of cinchona alkaloid-derived chiral catalysts and ligands have been developed and applied by organic chemists in catalytic asymmetric synthesis in rencent years. This review summarizes the recent progress made in this field over the past few years. Moreover, the related reaction mechanisms and future development prospects are also discussed.

Key words: Cinchona alkaloids, organic catalysts, chiral ligands, asymmetric synthesis, asymmetric catalysis