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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (05): 857-860. 上一篇    下一篇

研究简报

水相中Pd/C催化的杂环芳卤的还原偶联反应研究

裴文*，董华   

  1. (浙江工业大学化学工程与材料学院 杭州 310014)
  • 收稿日期:2007-06-27 修回日期:2007-10-11 发布日期:2008-05-20
  • 通讯作者: 裴文

Reductive Coupling of Heteroaryl Halides Catalyzed by Pd/C in Aqueous Media

PEI Wen*,DONG Hua   

  1. (College of Chemical Engineering and Materials, Zhejiang University of Technology, Hangzhou 310014)
  • Received:2007-06-27 Revised:2007-10-11 Published:2008-05-20
  • Contact: PEI Wen

PDF

1433

被引次数

8

在H2O-alcohol体系中通过Pd/C催化的还原偶联反应由杂环芳卤高收率的得到了二芳基化合物. 该方法操作简单, 环境友好, Pd/C可重复使用, 无需相转移催化剂也能得到较高收率. 讨论了醇、碱的种类和用量以及不同底物对反应收率的影响.

关键词: Pd/C, H2O-alcohol, 二芳基化合物, 偶联, 芳基卤

Hetero biaryls were prepared with high yields from heteroaryl halides by Pd/C-catalyzed reductive coupling reaction in a H2O-alcohol system. This method has advantages of environmental benignity, simplicity, the potential for recycling of catalyst, good yield and not using phase-transfer agent. The effects of various alcohols, bases and substrates on the reaction were discussed.

Key words: H2O-alcohol, coupling, biaryl, aryl halide, Pd/C