简易一锅合成新型5-取代P,O-型吲哚膦配体及其应用于钯催化芳基氯Suzuki-Miyaura偶联反应

doi:10.6023/cjoc202005069

有机化学 ›› 2020, Vol. 40 ›› Issue (10): 3338-3346.DOI: 10.6023/cjoc202005069 上一篇下一篇

所属专题：黄乃正院士七十华诞专辑

研究论文

简易一锅合成新型5-取代P,O-型吲哚膦配体及其应用于钯催化芳基氯Suzuki-Miyaura偶联反应

梁文斌^a, 杨宗潮^b, 蔡珮盈^a, 苏秋铭^b, 邝福儿^a,b

a 香港中文大学化学系香港;
b 香港理工大学应用生物及化学科技系香港

收稿日期:2020-05-26 修回日期:2020-07-03 发布日期:2020-07-17
通讯作者: 梁文斌, 杨宗潮, 邝福儿 E-mail:fykwong@cuhk.edu.hk
基金资助:
广东省基础与应用基础研究专项资金（No.2019A1515011357）以及中国香港研究资助局优配研究金（No.14304519）资助项目.

Facile One-Pot Assembly of New 5-Substituted P,O-Type Indolylphosphine Ligands for Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling of Aryl Chlorides

Leung Man Pan^a, Yeung Chung Chiu^b, Choy Pui Ying^a, So Chau Ming^b, Kwong Fuk Yee^a,b

a Department of Chemistry, The Chinese University of Hong Kong, Hong Kong;
b Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong

Received:2020-05-26 Revised:2020-07-03 Published:2020-07-17
Supported by:
Project supported by the Guangdong Basic and Applied Basic Research Foundation (No. 2019A1515011357), and the General Research Fund (GRF) from Research Grants Council of Hong Kong (RGC) (No. 14304519).

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摘要/Abstract

从容易获得且便宜的原材料出发，通过简单的一锅式组装方法合成了一种新的P，O-型吲哚基膦配体，并将其用于钯催化的芳基氯Suzuki-Miyaura交叉偶联反应，结果显示配体上的“取代基”能促进该反应的活性，其钯催化剂载量可降至0.01 mol%.

关键词: 钯, 配体设计, 交叉偶联, 膦, P,O-型配体

A series of P,O-type indolylphosphine ligands with different substituted variants have been synthesized by a simple one-pot protocol from readily available and inexpensive materials. These ligands show "substituent effect" with respected to the efficacy in promoting palladium-catalyzed Suzuki-Miyaura cross-coupling of aryl chlorides. This new Pd/L1 catalyst system particularly allows the catalyst loading reaching the level of 0.01 mol% Pd.

Key words: palladium, ligand design, cross-coupling, phosphine, P,O-ligand

引用此文

梁文斌, 杨宗潮, 蔡珮盈, 苏秋铭, 邝福儿. 简易一锅合成新型5-取代P,O-型吲哚膦配体及其应用于钯催化芳基氯Suzuki-Miyaura偶联反应[J]. 有机化学, 2020, 40(10): 3338-3346.

Leung Man Pan, Yeung Chung Chiu, Choy Pui Ying, So Chau Ming, Kwong Fuk Yee. Facile One-Pot Assembly of New 5-Substituted P,O-Type Indolylphosphine Ligands for Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling of Aryl Chlorides[J]. Chinese Journal of Organic Chemistry, 2020, 40(10): 3338-3346.

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简易一锅合成新型5-取代P,O-型吲哚膦配体及其应用于钯催化芳基氯Suzuki-Miyaura偶联反应

Facile One-Pot Assembly of New 5-Substituted P,O-Type Indolylphosphine Ligands for Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling of Aryl Chlorides

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