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封面介绍
Two transformations of vinyl cyclic carbamates and isocyanates under palladium catalysis have been successfully developed by Lu and co-workers on page 265. Linear and cyclic ureas that are highly significant for pharmaceutical chemistry, agricultural chemistry and materials science are produced in a controlled manner with good efficiency and selectivity. The key to this success is the choice of suitable phosphor-contained ligands to switch the chemoselectivity.
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封面介绍The recent advances in the synthesis of nine-membered N-heterocycles are reviewed by Qin, Zou, Nong, and Mo on page 130. Various new strategies have been developed to prepare nine-membered N-heterocycles, which have been successfully applied in the synthesis of natural products and pharmaceutically active molecules containing nine-membered ring scaffold through cyclization, cycloaddition, rearrangement, ring-expansion, and cascade reactions.
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封面介绍A naked-eye visible, “off-on” long-wavelength fluorescent probe based on N,N-(dimethylamino)naphthalenyl flavone is reported by Zhou, Ding, Zhao, Li and Luo on page 178. The probe showed high selectivity and low detection limits for biothiols. It could be used for the imaging of biothiols in living heptocarcinoma cells and in nude mice.
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封面介绍The daphnezomine A-type Daphniphyllum alkaloids consist of only three known members, namely daphnezomine A, daphnezomine B and dapholdhamine B. These alkaloids contain a unique aza-adamantane core along with nine contiguous stereogenic centers, thus presenting remarkable synthetic challenges. A concise synthesis of the tetracyclic core structure of daphnezomines A and B is reported by Hu, Chen, Jiang, and Xu on page 171.
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