有机化学 ›› 2015, Vol. 35 ›› Issue (3): 676-680.DOI: 10.6023/cjoc201412047 上一篇    下一篇

研究论文

铑催化苯醌磺酰化反应合成磺酰基醌类衍生物

王大伟, 余晓丽, 葛冰洋, 苗红艳, 丁玉强   

  1. 江南大学化学与材料工程学院 教育部食品胶体与生物技术重点实验室 无锡 214122
  • 收稿日期:2014-12-29 修回日期:2015-01-26 发布日期:2015-01-28
  • 通讯作者: 王大伟, 丁玉强 E-mail:wangdw@jiangnan.edu.cn
  • 基金资助:

    国家自然科学基金(No. 21401080)资助项目.

Synthesis of Sulfonyl Quinone Derivatives by Rh-Catalyzed Sulfonylation of Quinones

Wang Dawei, Yu Xiaoli, Ge Bingyang, Miao Hongyan, Ding Yuqiang   

  1. Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122
  • Received:2014-12-29 Revised:2015-01-26 Published:2015-01-28
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21401080).

报道了一种过渡金属铑催化的醌类与磺酰氯化合物的偶联反应, 实现了醌类的磺酰化反应. 在温和的反应条件下, 以较高的产率成功合成了一系列具有生物活性的磺酰基醌类化合物, 此反应不仅对苯醌具有较好的适应性, 对于萘醌底物也能取得较高的产率, 并提出了初步的反应机理.

关键词: 铑, 磺酰化, 交叉偶联, 醌, 磺酰基苯醌

The rhodium-catalyzed sulfonylation reaction of quinones with sulfonyl chloride compounds was developed, which provides an efficient and mild method of the synthesis of biologically active sulfonyl quinones with high yields. This methodology is also efficient for the coupling of naphthoquinone with sulfonyl chlorides. The possible reaction mechanism was also proposed.

Key words: rhodium, sulfonylation, cross-coupling, quinones, sulfonyl quinones